1gxz
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(New page: 200px<br /> <applet load="1gxz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gxz, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 16:33, 29 October 2007
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CRYSTAL STRUCTURE OF THE EUCARYOTIC MONO-ADP-RIBOSYLTRANSFERASE ART2.2; CRYSTAL FORM B (P212121)
Overview
The mammalian extracellular ADP-ribosyl transferases ART1 through ART5 are, sequence-related to each other. Among them ART2 is involved in immuno, regulation. The variant ART2.2 was expressed in the periplasm of, Escherichia coli and crystallized. Its structure was determined by X-ray, diffraction at 1.7A resolution in one crystal form and at slightly lower, resolutions in two others. The active center was indicated by a ligated, nicotinamide analogue, which also revealed a small induced-fit. The, centerpiece of the chainfold of ART2.2 agrees with those of all bacterial, ADP-ribosyl transferases. This correspondence and the nicotinamide, position were used to model the binding structure of the whole substrate, NAD(+) at ART2.2. Two of the bacterial enzymes are structurally more, closely ... [(full description)]
About this Structure
1GXZ is a [Single protein] structure of sequence from [Rattus norvegicus] with BRT as [ligand]. Active as [[1]], with EC number [2.4.2.31]. Full crystallographic information is available from [OCA].
Reference
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat., Mueller-Dieckmann C, Ritter H, Haag F, Koch-Nolte F, Schulz GE, J Mol Biol. 2002 Sep 27;322(4):687-96. PMID:12270706
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