2xxh
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxh OCA], [https://pdbe.org/2xxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxh RCSB], [https://www.ebi.ac.uk/pdbsum/2xxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxh OCA], [https://pdbe.org/2xxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxh RCSB], [https://www.ebi.ac.uk/pdbsum/2xxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution.
| |||||||||||
Categories: Large Structures | Rattus norvegicus | Aldegheri L | Austin NE | Ballantine S | Ballini E | Bax BD | Bradley DM | Clarke BP | DalNegro G | Harries M | Harris AJ | Harrison SA | Melarange RA | Mookherjee C | Mosley J | Oliosi B | Smith KJ | Thewlis KM | Ward SE | Woollard PM | Yusaf SP
