3k5g
From Proteopedia
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==Human bace-1 complex with bjc060== | ==Human bace-1 complex with bjc060== | ||
| - | <StructureSection load='3k5g' size='340' side='right' caption='[[3k5g]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3k5g' size='340' side='right'caption='[[3k5g]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3k5g]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3k5g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K5G FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJC:(1R,3S)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(1-METHYLETHYL)BENZYL]AMINO}PROPYL]-3-[1-METHYL-1-(2-OXOPIPERIDIN-1-YL)ETHYL]CYCLOHEXANECARBOXAMIDE'>BJC</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJC:(1R,3S)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(1-METHYLETHYL)BENZYL]AMINO}PROPYL]-3-[1-METHYL-1-(2-OXOPIPERIDIN-1-YL)ETHYL]CYCLOHEXANECARBOXAMIDE'>BJC</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k5g OCA], [https://pdbe.org/3k5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k5g RCSB], [https://www.ebi.ac.uk/pdbsum/3k5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k5g ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/3k5g_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/3k5g_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3k5g" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3k5g" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Rondeau | + | [[Category: Rondeau J-M]] |
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Current revision
Human bace-1 complex with bjc060
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