4b7r

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Current revision (02:42, 21 November 2024) (edit) (undo)
 
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<StructureSection load='4b7r' size='340' side='right'caption='[[4b7r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4b7r' size='340' side='right'caption='[[4b7r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b7r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/07/2009(h1n1)) Influenza a virus (a/california/07/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b7r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/07/2009(H1N1)) Influenza A virus (A/California/07/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b7j|4b7j]], [[4b7m|4b7m]], [[4b7n|4b7n]], [[4b7q|4b7q]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7r OCA], [https://pdbe.org/4b7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7r RCSB], [https://www.ebi.ac.uk/pdbsum/4b7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7r OCA], [https://pdbe.org/4b7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7r RCSB], [https://www.ebi.ac.uk/pdbsum/4b7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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[https://www.uniprot.org/uniprot/C7FH46_9INFA C7FH46_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boucher, C A.B]]
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[[Category: Boucher CAB]]
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[[Category: Collins, P J]]
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[[Category: Collins PJ]]
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[[Category: Gamblin, S J]]
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[[Category: Gamblin SJ]]
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[[Category: Haire, L F]]
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[[Category: Haire LF]]
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[[Category: Hay, A J]]
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[[Category: Hay AJ]]
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[[Category: Liu, J]]
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[[Category: Liu J]]
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[[Category: Martin, S R]]
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[[Category: Martin SR]]
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[[Category: Osterhaus, A D.M E]]
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[[Category: Osterhaus ADME]]
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[[Category: Schutten, M]]
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[[Category: Schutten M]]
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[[Category: Skehel, J J]]
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[[Category: Skehel JJ]]
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[[Category: Vachieri, S G]]
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[[Category: Vachieri SG]]
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[[Category: Vries, E van der]]
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[[Category: Walker PA]]
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[[Category: Walker, P A]]
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[[Category: Xiong X]]
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[[Category: Xiong, X]]
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[[Category: Van der Vries E]]
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[[Category: Antiviral resistance]]
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[[Category: Hydrolase]]
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[[Category: Nai]]
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[[Category: Neuraminidase inhibitor]]
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[[Category: Resistance]]
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[[Category: Zanamivir]]
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Current revision

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

PDB ID 4b7r

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