4dfh

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFH FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfh OCA], [https://pdbe.org/4dfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfh RCSB], [https://www.ebi.ac.uk/pdbsum/4dfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfh ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfh OCA], [https://pdbe.org/4dfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfh RCSB], [https://www.ebi.ac.uk/pdbsum/4dfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/NECT2_HUMAN NECT2_HUMAN]] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).<ref>PMID:26755705</ref> <ref>PMID:9657005</ref> (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).<ref>PMID:11602758</ref> <ref>PMID:9657005</ref>
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Crystal structure of cell adhesion molecule nectin-2/CD112 variable domain

PDB ID 4dfh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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