5b8c
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b8c OCA], [https://pdbe.org/5b8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b8c RCSB], [https://www.ebi.ac.uk/pdbsum/5b8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b8c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b8c OCA], [https://pdbe.org/5b8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b8c RCSB], [https://www.ebi.ac.uk/pdbsum/5b8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b8c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
High resolution structure of the human PD-1 in complex with pembrolizumab Fv
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