5w7e

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Current revision (04:54, 21 November 2024) (edit) (undo)
 
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<StructureSection load='5w7e' size='340' side='right'caption='[[5w7e]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='5w7e' size='340' side='right'caption='[[5w7e]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w7e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W7E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w7e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W7E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAW:(2S)-3-hydroxypropane-1,2-diyl+ditetradecanoate'>FAW</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aoah ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAW:[(2S)-3-oxidanyl-2-tetradecanoyloxy-propyl]+tetradecanoate'>FAW</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyloxyacyl_hydrolase Acyloxyacyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.77 3.1.1.77] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7e OCA], [https://pdbe.org/5w7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w7e RCSB], [https://www.ebi.ac.uk/pdbsum/5w7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7e OCA], [http://pdbe.org/5w7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w7e RCSB], [http://www.ebi.ac.uk/pdbsum/5w7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7e ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AOAH_MOUSE AOAH_MOUSE]] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055).<ref>PMID:12810692</ref> <ref>PMID:15155618</ref> <ref>PMID:17322564</ref> <ref>PMID:18779055</ref> <ref>PMID:19860560</ref> <ref>PMID:28622363</ref>
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[https://www.uniprot.org/uniprot/AOAH_MOUSE AOAH_MOUSE] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055).<ref>PMID:12810692</ref> <ref>PMID:15155618</ref> <ref>PMID:17322564</ref> <ref>PMID:18779055</ref> <ref>PMID:19860560</ref> <ref>PMID:28622363</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acyloxyacyl hydrolase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Gorelik, A]]
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[[Category: Gorelik A]]
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[[Category: Illes, K]]
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[[Category: Illes K]]
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[[Category: Nagar, B]]
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[[Category: Nagar B]]
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[[Category: Gdsl esterase]]
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[[Category: Hydrolase]]
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[[Category: Lipopolysaccharide]]
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[[Category: Lp]]
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[[Category: Saposin]]
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Current revision

Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with dimyristoyl phosphatidylcholine

PDB ID 5w7e

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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