6hjc

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Current revision (05:18, 21 November 2024) (edit) (undo)
 
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==Crystal structure of Loei River virus GP1 glycoprotein at pH 8.0==
==Crystal structure of Loei River virus GP1 glycoprotein at pH 8.0==
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<StructureSection load='6hjc' size='340' side='right' caption='[[6hjc]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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<StructureSection load='6hjc' size='340' side='right'caption='[[6hjc]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loei_river_mammarenavirus Loei river mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammarenavirus_loeiense Mammarenavirus loeiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HJC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1437126 Loei River mammarenavirus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjc OCA], [http://pdbe.org/6hjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hjc RCSB], [http://www.ebi.ac.uk/pdbsum/6hjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hjc OCA], [https://pdbe.org/6hjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hjc RCSB], [https://www.ebi.ac.uk/pdbsum/6hjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hjc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A023J4Z7_9VIRU A0A023J4Z7_9VIRU]] Glycoprotein G1: interacts with the host receptor.[HAMAP-Rule:MF_04084] Glycoprotein G2: class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.[HAMAP-Rule:MF_04084] Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084]
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[https://www.uniprot.org/uniprot/A0A023J4Z7_9VIRU A0A023J4Z7_9VIRU] Glycoprotein G1: interacts with the host receptor.[HAMAP-Rule:MF_04084] Glycoprotein G2: class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.[HAMAP-Rule:MF_04084] Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hjc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hjc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Loei river mammarenavirus]]
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[[Category: Large Structures]]
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[[Category: Bowden, T A]]
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[[Category: Mammarenavirus loeiense]]
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[[Category: Ng, W M]]
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[[Category: Bowden TA]]
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[[Category: Omari, K El]]
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[[Category: El Omari K]]
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[[Category: Pryce, R]]
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[[Category: Ng WM]]
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[[Category: Wagner, A]]
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[[Category: Pryce R]]
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[[Category: Watanabe, Y]]
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[[Category: Wagner A]]
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[[Category: Zeltina, A]]
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[[Category: Watanabe Y]]
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[[Category: Attachment]]
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[[Category: Zeltina A]]
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[[Category: Glycoprotein]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of Loei River virus GP1 glycoprotein at pH 8.0

PDB ID 6hjc

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