6k41

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<StructureSection load='6k41' size='340' side='right'caption='[[6k41]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6k41' size='340' side='right'caption='[[6k41]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6k41]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K41 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6K41 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K41 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CZX:4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole'>CZX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Gnb1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ADRA2B, ADRA2L1, ADRA2RL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CZX:4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole'>CZX</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k41 OCA], [https://pdbe.org/6k41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k41 RCSB], [https://www.ebi.ac.uk/pdbsum/6k41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k41 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6k41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k41 OCA], [http://pdbe.org/6k41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k41 RCSB], [http://www.ebi.ac.uk/pdbsum/6k41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k41 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
 
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== Function ==
 
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[[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_MOUSE GBB1_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. [[http://www.uniprot.org/uniprot/ADA2A_BOVIN ADA2A_BOVIN]] Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6k41" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6k41" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Brian K]]
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[[Category: Lysozyme]]
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[[Category: Daopeng Y]]
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[[Category: Kobilka, B K]]
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[[Category: Hongwei W]]
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[[Category: Liu, Z]]
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[[Category: Zhongmin L]]
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[[Category: Wang, H W]]
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[[Category: Yuan, D]]
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[[Category: Complex]]
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[[Category: Cryo-em]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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Current revision

cryo-EM structure of alpha2BAR-GoA complex

PDB ID 6k41

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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