1uhn
From Proteopedia
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'''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana''' | '''The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana''' | ||
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[[Category: Sato, M.]] | [[Category: Sato, M.]] | ||
[[Category: Shimizu, T.]] | [[Category: Shimizu, T.]] | ||
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Revision as of 08:14, 3 May 2008
The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana
Overview
Arabidopsis thaliana calcineurin B-like protein (AtCBL2) is a member of a recently identified family of calcineurin B-like calcium-binding proteins in A. thaliana. The crystal structure of AtCBL2 has been determined at 2.1 A resolution. The protein forms a compact alpha-helical structure with two pairs of EF-hand motifs. The structure is similar in overall folding topology to the structures of calcineurin B and neuronal calcium sensor 1, but differs significantly in local conformation. The two calcium ions are coordinated in the first and fourth EF-hand motifs, whereas the second and third EF-hand motifs are maintained in the open form by internal hydrogen bonding without coordination of calcium ions. Both a possible site and a possible mechanism for the target binding to AtCBL2 are discussed based on the three-dimensional structure.
About this Structure
1UHN is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
The crystal structure of the novel calcium-binding protein AtCBL2 from Arabidopsis thaliana., Nagae M, Nozawa A, Koizumi N, Sano H, Hashimoto H, Sato M, Shimizu T, J Biol Chem. 2003 Oct 24;278(43):42240-6. Epub 2003 Jul 19. PMID:12871972 Page seeded by OCA on Sat May 3 11:14:28 2008
