7a02

<table><tr><td colspan='2'>[[7a02]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A02 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B1995_14460, B2J90_04405, BACERE00183_02460, CNQ78_18995 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr>

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== Publication Abstract from PubMed ==

Bacillus cereus sensu lato is a group of Gram-positive endospore-forming bacteria with high ecological diversity. Their endospores are decorated with micrometer-long appendages of unknown identity and function. Here, we isolate endospore appendages (Enas) from the food poisoning outbreak strain B. cereus NVH 0075-95 and find proteinaceous fibers of two main morphologies: S- and L-Ena. By using cryoEM and 3D helical reconstruction of S-Enas, we show these to represent a novel class of Gram-positive pili. S-Enas consist of single domain subunits with jellyroll topology that are laterally stacked by beta-sheet augmentation. S-Enas are longitudinally stabilized by disulfide bonding through N-terminal connector peptides that bridge the helical turns. Together, this results in flexible pili that are highly resistant to heat, drought, and chemical damage. Phylogenomic analysis reveals a ubiquitous presence of the ena-gene cluster in the B. cereus group, which include species of clinical, environmental, and food importance. We propose Enas to represent a new class of pili specifically adapted to the harsh conditions encountered by bacterial spores.

Endospore Appendages: a novel pilus superfamily from the endospores of pathogenic Bacilli.,Pradhan B, Liedtke J, Sleutel M, Lindback T, Zegeye ED, O Sullivan K, Llarena AK, Brynildsrud O, Aspholm M, Remaut H EMBO J. 2021 May 25:e106887. doi: 10.15252/embj.2020106887. PMID:34031903<ref>PMID:34031903</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 7a02" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atcc 14579]]

[[Category: Aspholm, M]]

[[Category: Brynildsrud, O]]

[[Category: Liedtke, J]]

[[Category: Lindback, T]]

[[Category: Llarena, A K]]

[[Category: Pradhan, B]]

[[Category: Remaut, H]]

[[Category: Sleutel, M]]

[[Category: Unknown function]]