7uxv
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human triosephosphate isomerase G122R, also known as TPI-Manchester, is a thermolabile variant detected in a screening of more than 3400 individuals from a population in Ann Arbor, Michigan. Here, the crystallographic structure of G122R was solved to determine the molecular basis of its thermal stability. Structural analysis revealed an increase in the flexibility of residues at the dimer interface, even though R122 is about 20 A away, suggesting that long-range electrostatic interactions may play a key role in the mutation effect. | ||
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| + | Structural analysis of the TPI-Manchester, a thermolabile variant of human triosephosphate isomerase.,Romero JM Arch Biochem Biophys. 2024 Nov;761:110156. doi: 10.1016/j.abb.2024.110156. Epub , 2024 Sep 17. PMID:39299479<ref>PMID:39299479</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7uxv" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
human triosephosphate isomerase mutant G122R
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