7wkh

<table><tr><td colspan='2'>[[7wkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ctenopharyngodon_idella Ctenopharyngodon idella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WKH FirstGlance]. <br>

== Function ==

[https://www.uniprot.org/uniprot/Q2HZY8_CTEID Q2HZY8_CTEID]

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== Publication Abstract from PubMed ==

Teleost type I interferons (IFNs) are categorized into group I and II subgroups that bind to distinct receptors to activate antiviral responses. However, the interaction between ifn ligands and receptors has not fully been understood. In this study, the crystal structure of grass carp [Ctenopharyngodon idella (Ci)] IFNa has been solved at 1.58A and consists of six helices. The CiIFNa displays a typical structure of type I IFNs with a straight helix F and lacks a helix element in the AB loop. Superposition modeling identified several key residues involved in the interaction with receptors. It was found that CiIFNa bound to cytokine receptor family B (CRFB) 1, CRFB2, and CRFB5, and the three receptors could form heterodimeric receptor complexes. Furthermore, mutation of Leu27, Glu103, Lys117, and His165 markedly decreased the phosphorylation of signal transducer and activator of transcription (STAT) 1a induced by CiIFNa in the Epithelioma papulosum cyprini (EPC) cells, and Glu103 was shown to be required for the CiIFNa-activated antiviral activity. Interestingly, wild-type and mutant CiIFNa proteins did not alter the phosphorylation levels of STAT1b. Our results demonstrate that fish type I IFNs, although structurally conserved, interact with the receptors in a manner that may differ from mammalian homologs.

Structural and Functional Analyses of Type I IFNa Shed Light Into Its Interaction With Multiple Receptors in Fish.,Wang Z, Xu J, Feng J, Wu K, Chen K, Jia Z, Zhu X, Huang W, Zhao X, Liu Q, Wang B, Chen X, Wang J, Zou J Front Immunol. 2022 Mar 22;13:862764. doi: 10.3389/fimmu.2022.862764. eCollection, 2022. PMID:35392096<ref>PMID:35392096</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Ctenopharyngodon idella]]