1uj2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1uj2.gif|left|200px]]
[[Image:1uj2.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1uj2 |SIZE=350|CAPTION= <scene name='initialview01'>1uj2</scene>, resolution 1.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_1uj2", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=C5P:CYTIDINE-5&#39;-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1uj2| PDB=1uj2 | SCENE= }}
-
|RELATEDENTRY=[[1udw|1UDW]], [[1uej|1UEJ]], [[1uei|1UEI]], [[1ufq|1UFQ]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uj2 OCA], [http://www.ebi.ac.uk/pdbsum/1uj2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uj2 RCSB]</span>
+
-
}}
+
'''Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP'''
'''Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP'''
Line 31: Line 28:
[[Category: Matsuda, A.]]
[[Category: Matsuda, A.]]
[[Category: Suzuki, N N.]]
[[Category: Suzuki, N N.]]
-
[[Category: alpha/beta mononucleotide-binding hold]]
+
[[Category: Alpha/beta mononucleotide-binding hold]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:17:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:11:03 2008''
+

Revision as of 08:17, 3 May 2008

Image:1uj2.gif

Template:STRUCTURE 1uj2

Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP


Overview

Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine and cytidine and activates pharmacological ribonucleoside analogs. Here we present the crystal structures of human UCK alone and in complexes with a substrate, cytidine, a feedback inhibitor, CTP or UTP, and with phosphorylation products, CMP and ADP, respectively. Free UCK takes an alpha/beta mononucleotide binding fold and exists as a homotetramer with 222 symmetry. Upon inhibitor binding, one loop region was loosened, causing the UCK tetramer to be distorted. Upon cytidine binding, a large induced fit was observed at the uridine/cytidine binding site, which endows UCK with a strict specificity for pyrimidine ribonucleosides. The first UCK structure provided the structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase, which give clues for the design of novel antitumor and antiviral ribonucleoside analogs that inhibit RNA synthesis.

About this Structure

1UJ2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase., Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F, Structure. 2004 May;12(5):751-64. PMID:15130468 Page seeded by OCA on Sat May 3 11:17:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uj2"
Personal tools