8bdz

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Current revision (07:03, 21 November 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8bdz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_adw/991 Hepatitis B virus adw/991], [https://en.wikipedia.org/wiki/Hepatitis_B_virus_ayw/France/Tiollais/1979 Hepatitis B virus ayw/France/Tiollais/1979] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Malaya/302/1954(H1N1)) Influenza A virus (A/Malaya/302/1954(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BDZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[8bdz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_adw/991 Hepatitis B virus adw/991], [https://en.wikipedia.org/wiki/Hepatitis_B_virus_ayw/France/Tiollais/1979 Hepatitis B virus ayw/France/Tiollais/1979] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Malaya/302/1954(H1N1)) Influenza A virus (A/Malaya/302/1954(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BDZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bdz OCA], [https://pdbe.org/8bdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bdz RCSB], [https://www.ebi.ac.uk/pdbsum/8bdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bdz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bdz OCA], [https://pdbe.org/8bdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bdz RCSB], [https://www.ebi.ac.uk/pdbsum/8bdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bdz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Hepatitis B virus core antigen (HBc) with the insertion of four external domains of the influenza A M2 protein (HBc/4M2e) form virus-like particles whose structure was studied using a combination of molecular modeling and cryo-electron microscopy (cryo-EM). It was also shown that self-assembling of the particles occurs inside bacterial cells, but despite the big inner volume of the core shell particle, purified HBc/4M2e contain an insignificant amount of bacterial proteins. It was shown that a fragment of the M2e corresponding to 4M2e insertion is prone to formation of amyloid-like fibrils. However, as the part of the immunodominant loop, M2e insertion does not show a tendency to intermolecular interaction. A full-atomic HBc-4M2e model with the resolution of about 3 A (3.13 A for particles of capital TE, Cyrillic = 4 symmetry, 3.7 A for particles of capital TE, Cyrillic = 3 symmetry) was obtained by molecular modeling methods based on cryo-EM data.
Hepatitis B virus core antigen (HBc) with the insertion of four external domains of the influenza A M2 protein (HBc/4M2e) form virus-like particles whose structure was studied using a combination of molecular modeling and cryo-electron microscopy (cryo-EM). It was also shown that self-assembling of the particles occurs inside bacterial cells, but despite the big inner volume of the core shell particle, purified HBc/4M2e contain an insignificant amount of bacterial proteins. It was shown that a fragment of the M2e corresponding to 4M2e insertion is prone to formation of amyloid-like fibrils. However, as the part of the immunodominant loop, M2e insertion does not show a tendency to intermolecular interaction. A full-atomic HBc-4M2e model with the resolution of about 3 A (3.13 A for particles of capital TE, Cyrillic = 4 symmetry, 3.7 A for particles of capital TE, Cyrillic = 3 symmetry) was obtained by molecular modeling methods based on cryo-EM data.
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Inside and outside of virus-like particles HBc and HBc/4M2e: A comprehensive study of the structure.,Egorov VV, Shvetsov AV, Pichkur EB, Shaldzhyan AA, Zabrodskaya YA, Vinogradova DS, Nekrasov PA, Gorshkov AN, Garmay YP, Kovaleva AA, Stepanova LA, Tsybalova LM, Shtam TA, Myasnikov AG, Konevega AL Biophys Chem. 2022 Dec 5;293:106943. doi: 10.1016/j.bpc.2022.106943. PMID:36495688<ref>PMID:36495688</ref>
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Inside and outside of virus-like particles HBc and HBc/4M2e: A comprehensive study of the structure.,Egorov VV, Shvetsov AV, Pichkur EB, Shaldzhyan AA, Zabrodskaya YA, Vinogradova DS, Nekrasov PA, Gorshkov AN, Garmay YP, Kovaleva AA, Stepanova LA, Tsybalova LM, Shtam TA, Myasnikov AG, Konevega AL Biophys Chem. 2023 Feb;293:106943. doi: 10.1016/j.bpc.2022.106943. Epub 2022 Dec , 5. PMID:36495688<ref>PMID:36495688</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 8bdz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 8bdz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>

Current revision

Hepatitis B virus core antigen (HBc) with the insertion of four external domains of the influenza A M2 protein (HBc/4M2e) with T=4 topology

PDB ID 8bdz

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