8di4

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<table><tr><td colspan='2'>[[8di4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DI4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8di4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DI4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.016&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.016&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=S9I:2-methyl-6-{[(1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy}-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrimidin-4-amine'>S9I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=S9I:2-methyl-6-[[(1~{S},2~{S})-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy]-~{N}-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrimidin-4-amine'>S9I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8di4 OCA], [https://pdbe.org/8di4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8di4 RCSB], [https://www.ebi.ac.uk/pdbsum/8di4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8di4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8di4 OCA], [https://pdbe.org/8di4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8di4 RCSB], [https://www.ebi.ac.uk/pdbsum/8di4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8di4 ProSAT]</span></td></tr>
</table>
</table>

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Discovery of MK-8189, a highly potent and selective PDE10A inhibitor for the treatment of schizophrenia

PDB ID 8di4

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