8k8j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:31, 21 November 2024) (edit) (undo)
 
Line 8: Line 8:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8j OCA], [https://pdbe.org/8k8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8j RCSB], [https://www.ebi.ac.uk/pdbsum/8k8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k8j OCA], [https://pdbe.org/8k8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k8j RCSB], [https://www.ebi.ac.uk/pdbsum/8k8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k8j ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
+
<div style="background-color:#fffaf0;">
-
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
+
== Publication Abstract from PubMed ==
-
== Function ==
+
The G-protein-coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1-G(i) complexes in synthetic agonist-bound forms have been resolved to date. However, the commercial drug recognition and G(q) coupling mechanisms of CB1 remain elusive. Herein, the cryo-electron microscopy (cryo-EM) structure of CB1-G(q) complex, in fenofibrate-bound form, at near-atomic resolution, is reported. The structure elucidates the delicate mechanisms of the precise fenofibrate recognition and G(q) protein coupling by CB1 and will facilitate future drug discovery and design.
-
[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
+
 
 +
Fenofibrate Recognition and G(q) Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1.,Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F, Wang J Adv Sci (Weinh). 2024 Apr;11(14):e2306311. doi: 10.1002/advs.202306311. Epub 2024 , Jan 31. PMID:38298116<ref>PMID:38298116</ref>
 +
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 8k8j" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>

Current revision

Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex

PDB ID 8k8j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8k8j"
Personal tools