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1ukv
From Proteopedia
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[[Image:1ukv.gif|left|200px]] | [[Image:1ukv.gif|left|200px]] | ||
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'''Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase''' | '''Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase''' | ||
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[[Category: Waldmann, H.]] | [[Category: Waldmann, H.]] | ||
[[Category: Watzke, A.]] | [[Category: Watzke, A.]] | ||
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| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Vesicular transport]] |
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Revision as of 08:22, 3 May 2008
Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Overview
Rab/Ypt guanosine triphosphatases (GTPases) represent a family of key membrane traffic regulators in eukaryotic cells whose function is governed by the guanosine diphosphate (GDP) dissociation inhibitor (RabGDI). Using a combination of chemical synthesis and protein engineering, we generated and crystallized the monoprenylated Ypt1:RabGDI complex. The structure of the complex was solved to 1.5 angstrom resolution and provides a structural basis for the ability of RabGDI to inhibit the release of nucleotide by Rab proteins. Isoprenoid binding requires a conformational change that opens a cavity in the hydrophobic core of its domain II. Analysis of the structure provides a molecular basis for understanding a RabGDI mutant that causes mental retardation in humans.
About this Structure
1UKV is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase., Rak A, Pylypenko O, Durek T, Watzke A, Kushnir S, Brunsveld L, Waldmann H, Goody RS, Alexandrov K, Science. 2003 Oct 24;302(5645):646-50. PMID:14576435 Page seeded by OCA on Sat May 3 11:22:00 2008
