1ul2
From Proteopedia
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[[Image:1ul2.jpg|left|200px]] | [[Image:1ul2.jpg|left|200px]] | ||
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'''Solution Conformation of alpha-Conotoxin GIC''' | '''Solution Conformation of alpha-Conotoxin GIC''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UL2 is a [[Single protein]] structure | + | 1UL2 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: McIntosh, J M.]] | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B M.]] | [[Category: Olivera, B M.]] | ||
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| - | [[Category: | + | [[Category: Beta-turn]] |
| - | [[Category: | + | [[Category: C-terminal amidation]] |
| - | [[Category: | + | [[Category: Two disulfide bond]] |
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Revision as of 08:22, 3 May 2008
Solution Conformation of alpha-Conotoxin GIC
Overview
Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC.
About this Structure
1UL2 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:14992691 Page seeded by OCA on Sat May 3 11:22:27 2008
