3hx6
From Proteopedia
(Difference between revisions)
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<StructureSection load='3hx6' size='340' side='right'caption='[[3hx6]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3hx6' size='340' side='right'caption='[[3hx6]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3hx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3hx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HX6 FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx6 OCA], [https://pdbe.org/3hx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx6 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx6 OCA], [https://pdbe.org/3hx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx6 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/PILY1_PSEAE PILY1_PSEAE] Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili (PubMed:25389296). Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity).[UniProtKB:S0HPF7]<ref>PMID:25389296</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx6_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx6_consurf.spt"</scriptWhenChecked> | ||
- | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: | + | [[Category: Pseudomonas aeruginosa]] |
- | [[Category: | + | [[Category: Orans J]] |
- | [[Category: | + | [[Category: Redinbo MR]] |
- | + | ||
- | + |
Current revision
Crystal structure of Pseudomonas aeruginosa PilY1 C-terminal domain
|