1ulh

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[[Image:1ulh.jpg|left|200px]]
[[Image:1ulh.jpg|left|200px]]
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{{Structure
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|PDB= 1ulh |SIZE=350|CAPTION= <scene name='initialview01'>1ulh</scene>, resolution 2.31&Aring;
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The line below this paragraph, containing "STRUCTURE_1ulh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= trps ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ulh| PDB=1ulh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ulh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulh OCA], [http://www.ebi.ac.uk/pdbsum/1ulh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ulh RCSB]</span>
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'''A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase'''
'''A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase'''
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[[Category: Sengoku, T.]]
[[Category: Sengoku, T.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
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[[Category: aminoacylation]]
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[[Category: Aminoacylation]]
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[[Category: angiostatic cytokine]]
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[[Category: Angiostatic cytokine]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:23:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:11:57 2008''
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Revision as of 08:23, 3 May 2008

Image:1ulh.jpg

Template:STRUCTURE 1ulh

A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase


Overview

Human tryptophanyl-tRNA synthetase (TrpRS) is secreted into the extracellular region of vascular endothelial cells. The splice variant form (mini TrpRS) functions in vascular endothelial cell apoptosis as an angiostatic cytokine. In contrast, the closely related human tyrosyl-tRNA synthetase (TyrRS) functions as an angiogenic cytokine in its truncated form (mini TyrRS). Here, we determined the crystal structure of human mini TrpRS at a resolution of 2.3 A and compared the structure with those of prokaryotic TrpRS and human mini TyrRS. Deletion of the tRNA anticodon-binding (TAB) domain insertion, consisting of eight residues in the human TrpRS, abolished the enzyme's apoptotic activity for endothelial cells, whereas its translational catalysis and cell-binding activities remained unchanged. Thus, we have identified the inserted peptide motif that activates the angiostatic signaling.

About this Structure

1ULH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase., Kise Y, Lee SW, Park SG, Fukai S, Sengoku T, Ishii R, Yokoyama S, Kim S, Nureki O, Nat Struct Mol Biol. 2004 Feb;11(2):149-56. Epub 2004 Jan 11. PMID:14730354 Page seeded by OCA on Sat May 3 11:23:29 2008

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