4elk
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elk OCA], [https://pdbe.org/4elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elk RCSB], [https://www.ebi.ac.uk/pdbsum/4elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elk OCA], [https://pdbe.org/4elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elk RCSB], [https://www.ebi.ac.uk/pdbsum/4elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR alpha-chains and TCR beta-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells. | ||
| + | |||
| + | Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.,Girardi E, Maricic I, Wang J, Mac TT, Iyer P, Kumar V, Zajonc DM Nat Immunol. 2012 Sep;13(9):851-6. doi: 10.1038/ni.2371. Epub 2012 Jul 22. PMID:22820602<ref>PMID:22820602</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4elk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of the Hy19.3 type II NKT TCR
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Categories: Large Structures | Mus musculus | Girardi E | Iyer P | Kumar V | Mac TT | Maricic I | Wang J | Zajonc DM
