4gkz
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gkz OCA], [https://pdbe.org/4gkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gkz RCSB], [https://www.ebi.ac.uk/pdbsum/4gkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gkz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gkz OCA], [https://pdbe.org/4gkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gkz RCSB], [https://www.ebi.ac.uk/pdbsum/4gkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gkz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Successful immunity requires that a limited pool of alphabeta T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented by 'self' major histocompatibility complex (pMHC) molecules. Structures of unligated and ligated MHC class-I-restricted TCRs with different ligands, supplemented with biophysical analyses, have revealed a number of important mechanisms that govern TCR mediated antigen recognition. HA1.7 TCR binding to the influenza hemagglutinin antigen (HA(306-318)) presented by HLA-DR1 or HLA-DR4 represents an ideal system for interrogating pMHC-II antigen recognition. Accordingly, we solved the structure of the unligated HA1.7 TCR and compared it to both complex structures. Despite a relatively rigid binding mode, HA1.7 T-cells could tolerate mutations in key contact residues within the peptide epitope. Thermodynamic analysis revealed that limited plasticity and extreme favorable entropy underpinned the ability of the HA1.7 T-cell clone to cross-react with HA(306-318) presented by multiple MHC-II alleles. | ||
+ | |||
+ | Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.,Holland CJ, Rizkallah PJ, Vollers S, Calvo-Calle JM, Madura F, Fuller A, Sewell AK, Stern LJ, Godkin A, Cole DK Sci Rep. 2012;2:629. doi: 10.1038/srep00629. Epub 2012 Sep 4. PMID:22953050<ref>PMID:22953050</ref> | ||
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+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
+ | <div class="pdbe-citations 4gkz" style="background-color:#fffaf0;"></div> | ||
+ | == References == | ||
+ | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> |
Current revision
HA1.7, a MHC class II restricted TCR specific for haemagglutinin
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