8xl9

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Current revision (07:31, 27 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xl9 is ON HOLD until Paper Publication
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==Structure of human pyruvate carboxylase==
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<StructureSection load='8xl9' size='340' side='right'caption='[[8xl9]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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Authors: Zhou, F.Y., Zhang, Y.Y., Zhou, Q., Hu, Q.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xl9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XL9 FirstGlance]. <br>
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Description: Structure of human pyruvate carboxylase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
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[[Category: Zhou, F.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xl9 OCA], [https://pdbe.org/8xl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xl9 RCSB], [https://www.ebi.ac.uk/pdbsum/8xl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xl9 ProSAT]</span></td></tr>
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[[Category: Zhou, Q]]
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</table>
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[[Category: Hu, Q]]
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== Disease ==
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[[Category: Zhang, Y.Y]]
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[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:[https://omim.org/entry/266150 266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
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== Function ==
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[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hu Q]]
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[[Category: Zhang YY]]
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[[Category: Zhou FY]]
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[[Category: Zhou Q]]

Current revision

Structure of human pyruvate carboxylase

PDB ID 8xl9

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