8xl9
From Proteopedia
(Difference between revisions)
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- | '''Unreleased structure''' | ||
- | + | ==Structure of human pyruvate carboxylase== | |
- | + | <StructureSection load='8xl9' size='340' side='right'caption='[[8xl9]], [[Resolution|resolution]] 2.61Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[8xl9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XL9 FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.61Å</td></tr> | |
- | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr> |
- | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xl9 OCA], [https://pdbe.org/8xl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xl9 RCSB], [https://www.ebi.ac.uk/pdbsum/8xl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xl9 ProSAT]</span></td></tr> |
- | [[Category: | + | </table> |
- | [[Category: | + | == Disease == |
- | [[Category: | + | [https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:[https://omim.org/entry/266150 266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia. |
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Hu Q]] | ||
+ | [[Category: Zhang YY]] | ||
+ | [[Category: Zhou FY]] | ||
+ | [[Category: Zhou Q]] |
Current revision
Structure of human pyruvate carboxylase
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Categories: Homo sapiens | Large Structures | Hu Q | Zhang YY | Zhou FY | Zhou Q