1ump

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[[Image:1ump.gif|left|200px]]
[[Image:1ump.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ump |SIZE=350|CAPTION= <scene name='initialview01'>1ump</scene>, resolution 2.13&Aring;
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The line below this paragraph, containing "STRUCTURE_1ump", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Sqa+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=SQA:2-AZASQUALENE'>SQA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ump| PDB=1ump | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ump FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ump OCA], [http://www.ebi.ac.uk/pdbsum/1ump PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ump RCSB]</span>
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}}
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'''GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE'''
'''GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE'''
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[[Category: Reinert, D J.]]
[[Category: Reinert, D J.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: cholesterol biosynthesis]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: monotopic membrane protein]]
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[[Category: Monotopic membrane protein]]
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[[Category: oxidosqualene cyclase]]
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[[Category: Oxidosqualene cyclase]]
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[[Category: triterpene cyclase]]
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[[Category: Triterpene cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:26:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:12:26 2008''
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Revision as of 08:26, 3 May 2008

Image:1ump.gif

Template:STRUCTURE 1ump

GEOMETRY OF TRITERPENE CONVERSION TO PENTACARBOCYCLIC HOPENE


Overview

The membrane protein squalene-hopene cyclase was cocrystallized with 2-azasqualene and analyzed by X-ray diffraction to 2.13 A resolution. The conformation of this close analog was clearly established, and it agreed with the common textbook presentation. The bound squalene undergoes only small conformational changes during the formation of rings A through D, thus requiring no intermediate. However, ring E formation is hindered by an entropic barrier, which may explain its absence in the steroids. The structure analysis revealed a mobile region between the active center cavity and the membrane, which may melt, opening a passage for squalene and hopene.

About this Structure

1UMP is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Reference

Conversion of squalene to the pentacarbocyclic hopene., Reinert DJ, Balliano G, Schulz GE, Chem Biol. 2004 Jan;11(1):121-6. PMID:15113001 Page seeded by OCA on Sat May 3 11:26:12 2008

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