9e4q

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m (Protected "9e4q" [edit=sysop:move=sysop])
Current revision (06:20, 4 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9e4q is ON HOLD
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==A DARPin fused to the 3TEL crystallization chaperone via a gly-gly-gly fusion==
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<StructureSection load='9e4q' size='340' side='right'caption='[[9e4q]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
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Authors: Pedroza Romo, M.J., Noakes, E., Soleimani, S., Smith, T., Doukov, T., Moody, J.D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9e4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E4Q FirstGlance]. <br>
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Description: A DARPin fused to the 3TEL crystallization chaperone via a gly-gly-gly fusion
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Pedroza Romo, M.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e4q OCA], [https://pdbe.org/9e4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e4q RCSB], [https://www.ebi.ac.uk/pdbsum/9e4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e4q ProSAT]</span></td></tr>
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[[Category: Noakes, E]]
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</table>
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[[Category: Smith, T]]
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== Disease ==
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[[Category: Doukov, T]]
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[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN] Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).<ref>PMID:12203785</ref> Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:[https://omim.org/entry/131440 131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:[https://omim.org/entry/601626 601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.
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[[Category: Soleimani, S]]
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== Function ==
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[[Category: Moody, J.D]]
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[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Doukov T]]
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[[Category: Moody JD]]
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[[Category: Noakes E]]
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[[Category: Pedroza Romo MJ]]
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[[Category: Smith T]]
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[[Category: Soleimani S]]

Current revision

A DARPin fused to the 3TEL crystallization chaperone via a gly-gly-gly fusion

PDB ID 9e4q

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