8yn0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (20:00, 11 December 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8yn0 is ON HOLD until 2026-03-10
+
==Crystal structure of NRG1C in complex with EDS1-SAG101-(ADPr-ATP)==
-
 
+
<StructureSection load='8yn0' size='340' side='right'caption='[[8yn0]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8yn0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YN0 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yn0 OCA], [https://pdbe.org/8yn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yn0 RCSB], [https://www.ebi.ac.uk/pdbsum/8yn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yn0 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/EDS1C_ARATH EDS1C_ARATH] Positive regulator of basal resistance and of effector-triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation (PubMed:22158819). Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling (PubMed:19578402). Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid (PubMed:11574472). Nuclear localization is essential for basal and TNL-conditioned immunity and for reprogramming defense gene expression, while cytoplasmic EDS1 is required to induce a complete immune response (PubMed:20617163). Heterodimerization with PAD4 and/or SGA101 is necessary for TNL-mediated effector-triggered immunity (PubMed:24331460). Contributes to nonhost resistance against E.amylovora (PubMed:22316300). Loss of EDS1-PAD4 interaction compromises basal but not TNL-triggered resistance (PubMed:21434927). Necessary for systemic acquired resistance (SAR) signal generation and perception (PubMed:24755512). Has no direct lipase activity (PubMed:16040633). Putative lipase activity is dispensable for immune functions (PubMed:24331460).<ref>PMID:10077677</ref> <ref>PMID:11574472</ref> <ref>PMID:19578402</ref> <ref>PMID:20617163</ref> <ref>PMID:21434927</ref> <ref>PMID:22158819</ref> <ref>PMID:22316300</ref> <ref>PMID:24755512</ref> <ref>PMID:16040633</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arabidopsis thaliana]]
 +
[[Category: Large Structures]]
 +
[[Category: Chai J]]
 +
[[Category: Huang S]]
 +
[[Category: Xiao Y]]

Current revision

Crystal structure of NRG1C in complex with EDS1-SAG101-(ADPr-ATP)

PDB ID 8yn0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8yn0"
Personal tools