8z03

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m (Protected "8z03" [edit=sysop:move=sysop])
Current revision (20:02, 11 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8z03 is ON HOLD until Paper Publication
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==Lactate bound to human GTP-specific succinyl-CoA synthetase==
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<StructureSection load='8z03' size='340' side='right'caption='[[8z03]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8z03]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z03 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z03 OCA], [https://pdbe.org/8z03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z03 RCSB], [https://www.ebi.ac.uk/pdbsum/8z03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z03 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN] Fatal infantile lactic acidosis with methylmalonic aciduria. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SUCA_HUMAN SUCA_HUMAN] Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.[HAMAP-Rule:MF_03222]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang H]]
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[[Category: Li LT]]
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[[Category: Liu RL]]
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[[Category: Ren XL]]
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[[Category: Zhang Y]]
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[[Category: Zhao YM]]

Current revision

Lactate bound to human GTP-specific succinyl-CoA synthetase

PDB ID 8z03

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OCA

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