9k8w

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m (Protected "9k8w" [edit=sysop:move=sysop])
Current revision (20:15, 11 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9k8w is ON HOLD
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==Crystal structure of the calcium indicator GCaMP6s-BrUS in calcium-bound state==
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<StructureSection load='9k8w' size='340' side='right'caption='[[9k8w]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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Authors: Varfolomeeva, L.A., Simonyan, T.R., Mamontova, A.V., Bogdanov, A.M., Popov, V.O., Boyko, K.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9k8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K8W FirstGlance]. <br>
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Description: Crystal structure of the calcium indicator GCaMP6s-BrUS in calcium-bound state
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene></td></tr>
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[[Category: Varfolomeeva, L.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k8w OCA], [https://pdbe.org/9k8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k8w RCSB], [https://www.ebi.ac.uk/pdbsum/9k8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k8w ProSAT]</span></td></tr>
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[[Category: Boyko, K.M]]
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</table>
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[[Category: Mamontova, A.V]]
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== Disease ==
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[[Category: Bogdanov, A.M]]
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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[[Category: Simonyan, T.R]]
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== Function ==
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[[Category: Popov, V.O]]
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Bogdanov AM]]
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[[Category: Boyko KM]]
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[[Category: Mamontova AV]]
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[[Category: Popov VO]]
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[[Category: Simonyan TR]]
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[[Category: Varfolomeeva LA]]

Current revision

Crystal structure of the calcium indicator GCaMP6s-BrUS in calcium-bound state

PDB ID 9k8w

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