1upg

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[[Image:1upg.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upg OCA], [http://www.ebi.ac.uk/pdbsum/1upg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1upg RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE QUORUM-SENSING PROTEIN TRAM FROM AGROBACTERIUM TUMEFACIENS'''
'''CRYSTAL STRUCTURE OF THE QUORUM-SENSING PROTEIN TRAM FROM AGROBACTERIUM TUMEFACIENS'''
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[[Category: Marco, S Di.]]
[[Category: Marco, S Di.]]
[[Category: Vannini, A.]]
[[Category: Vannini, A.]]
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[[Category: conjugation]]
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[[Category: Conjugation]]
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[[Category: negative regulator]]
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[[Category: Negative regulator]]
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[[Category: quorum-sensing]]
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[[Category: Quorum-sensing]]
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[[Category: repressor]]
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[[Category: Repressor]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:13:32 2008''
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Revision as of 08:32, 3 May 2008

Image:1upg.gif


PDB ID 1upg

Drag the structure with the mouse to rotate
1upg, resolution 1.80Å ()
Non-Standard Residues:
Related: 1us6
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE QUORUM-SENSING PROTEIN TRAM FROM AGROBACTERIUM TUMEFACIENS


Overview

Transfer of the tumor-inducing plasmid in Agrobacterium tumefaciens is controlled by a quorum-sensing system whose main components are the transcriptional regulator TraR and its autoinducer. This system allows bacteria to synchronize infection of the host plant when a "quorum" of cells has been reached. TraM is an A. tumefaciens protein involved in the regulation of this system because it binds to TraR and prevents it from binding DNA. As a first step to understanding the molecular basis for the regulation of TraR by TraM, we have determined the crystal structure of TraM at 1.65 A resolution. This protein is packed as a dimer, with each monomer consisting mainly of two antiparallel alpha helices. Monomers are tightly associated, with a large hydrophobic area buried upon dimerization. Secondly, we characterized the TraR-TraM complex in vitro. TraM (11.4 kDa, monomer molecular mass) binds tightly TraR (27 kDa, monomer molecular mass) forming a stable oligomeric complex that likely accounts for two TraR and two TraM dimers.

About this Structure

1UPG is a Single protein structure of sequence from Agrobacterium tumefaciens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the quorum-sensing protein TraM and its interaction with the transcriptional regulator TraR., Vannini A, Volpari C, Di Marco S, J Biol Chem. 2004 Jun 4;279(23):24291-6. Epub 2004 Mar 24. PMID:15044488 Page seeded by OCA on Sat May 3 11:32:00 2008

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