1ya3

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Revision as of 18:10, 12 November 2007

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spinqualitylabelsall models 1ya3, resolution 2.34Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The S810L mutation within the human mineralocorticoid receptor (MR S810L), induces severe hypertension and switches progesterone from antagonist to, agonist. Here we report the crystal structures of the ligand-binding, domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first, for MR, identify the specific contacts created by Leu810 and clarify the, mechanism of activation of MR S810L.

Disease

Known diseases associated with this structure: Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy OMIM:[600983], Pseudohypoaldosteronism type I, autosomal dominant OMIM:[600983]

About this Structure

1YA3 is a Single protein structure of sequence from Homo sapiens with STR as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension., Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME, Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22. PMID:15908963

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