1upt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1upt.jpg|left|200px]]
[[Image:1upt.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1upt |SIZE=350|CAPTION= <scene name='initialview01'>1upt</scene>, resolution 1.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_1upt", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+G'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1upt| PDB=1upt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upt OCA], [http://www.ebi.ac.uk/pdbsum/1upt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1upt RCSB]</span>
+
-
}}
+
'''STRUCTURE OF A COMPLEX OF THE GOLGIN-245 GRIP DOMAIN WITH ARL1'''
'''STRUCTURE OF A COMPLEX OF THE GOLGIN-245 GRIP DOMAIN WITH ARL1'''
Line 30: Line 27:
[[Category: Veprintsev, D B.]]
[[Category: Veprintsev, D B.]]
[[Category: Williams, R L.]]
[[Category: Williams, R L.]]
-
[[Category: arl1]]
+
[[Category: Arl1]]
-
[[Category: g-protein]]
+
[[Category: G-protein]]
-
[[Category: golgi]]
+
[[Category: Golgi]]
-
[[Category: golgin]]
+
[[Category: Golgin]]
-
[[Category: golgin-245]]
+
[[Category: Golgin-245]]
-
[[Category: grip]]
+
[[Category: Grip]]
-
[[Category: grip dimer]]
+
[[Category: Grip dimer]]
-
[[Category: gtpase]]
+
[[Category: Gtpase]]
-
[[Category: protein sorting]]
+
[[Category: Protein sorting]]
-
[[Category: vesicle trafficking]]
+
[[Category: Vesicle trafficking]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:32:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:13:40 2008''
+

Revision as of 08:32, 3 May 2008

Image:1upt.jpg

Template:STRUCTURE 1upt

STRUCTURE OF A COMPLEX OF THE GOLGIN-245 GRIP DOMAIN WITH ARL1


Overview

Golgins are large coiled-coil proteins that play a role in Golgi structure and vesicle traffic. The Arf-like GTPase Arl1 regulates the translocation of GRIP domain-containing golgins to Golgi membranes. We report here the 1.7 A resolution structure of human Arl1-GTP in a complex with the GRIP domain of golgin-245. The structure reveals that the GRIP domain consists of an S-shaped arrangement of three helices. The domain forms a homodimer that binds two Arl1-GTPs using two helices from each monomer. The structure is consistent with golgin-245 forming parallel coiled-coils and suggests how Arl1-GTP/GRIP complexes interact with Golgi membranes via the N termini of Arl1-GTP and the C-terminal tails of the GRIP domains. In cells, bivalent association with Arl1-GTP would increase residence time of the golgins on Golgi membranes. Despite no conservation of sequence, topology, or even helical direction, several other effectors form similar interactions with small GTPases via a pair of alpha helices, suggesting a common structural basis for effector recognition.

About this Structure

1UPT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus., Panic B, Perisic O, Veprintsev DB, Williams RL, Munro S, Mol Cell. 2003 Oct;12(4):863-74. PMID:14580338 Page seeded by OCA on Sat May 3 11:32:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1upt"
Personal tools