9c5a
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==AP-3 Arf1 dimeric interface, focused refinement== | |
| - | + | <StructureSection load='9c5a' size='340' side='right'caption='[[9c5a]], [[Resolution|resolution]] 4.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9c5a]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C5A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c5a OCA], [https://pdbe.org/9c5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c5a RCSB], [https://www.ebi.ac.uk/pdbsum/9c5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c5a ProSAT]</span></td></tr> |
| - | [[Category: Baker | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AP3B1_HUMAN AP3B1_HUMAN] Hermansky-Pudlak syndrome due to AP3B1 deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AP3B1_HUMAN AP3B1_HUMAN] Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.<ref>PMID:9151686</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baker RW]] | ||
| + | [[Category: Begley MC]] | ||
Current revision
AP-3 Arf1 dimeric interface, focused refinement
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