9cxn

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Current revision (06:31, 18 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9cxn is ON HOLD until Paper Publication
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==Crystal structure of Human FN3K bound with AMPPNP and DMF==
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<StructureSection load='9cxn' size='340' side='right'caption='[[9cxn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9cxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CXN FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A0O:(3~{S},4~{R},5~{R})-1-morpholin-4-yl-3,4,5,6-tetrakis(oxidanyl)hexan-2-one'>A1A0O</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cxn OCA], [https://pdbe.org/9cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cxn RCSB], [https://www.ebi.ac.uk/pdbsum/9cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cxn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FN3K_HUMAN FN3K_HUMAN] Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).[UniProtKB:Q9ER35]<ref>PMID:11016445</ref> <ref>PMID:11522682</ref> <ref>PMID:11975663</ref> <ref>PMID:14633848</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Garg A]]
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[[Category: Joshua-Tor L]]
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[[Category: On KF]]

Current revision

Crystal structure of Human FN3K bound with AMPPNP and DMF

PDB ID 9cxn

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