9f80

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Current revision (06:32, 18 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9f80 is ON HOLD until Paper Publication
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==Crystal structure of Rv2242 regulator C-terminal fragment (161-414)==
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<StructureSection load='9f80' size='340' side='right'caption='[[9f80]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9f80]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F80 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.027&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f80 OCA], [https://pdbe.org/9f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f80 RCSB], [https://www.ebi.ac.uk/pdbsum/9f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f80 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y2242_MYCTU Y2242_MYCTU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MabR (Rv2242), a PucR-type transcription factor, plays a crucial role in regulating mycolic acid biosynthesis in Mycobacterium tuberculosis. To understand its regulatory mechanisms, we determined the crystal structures of its N-terminal and C-terminal domains. The N-terminal domain adopts a globin-like fold, while the C-terminal domain comprises an alpha/beta GGDEF domain and an all-alpha effector domain with a helix-turn-helix DNA-binding motif. This unique domain combination is specific to Actinomycetes. Biochemical and computational studies suggest that full-length MabR forms both dimeric and tetrameric assemblies in solution. Structural analysis revealed two distinct dimerization interfaces within the N- and C-terminal domains, further supporting a tetrameric organization. These findings provide valuable insights into the domain architecture, oligomeric state, and potential regulatory mechanisms of MabR.
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Authors: Megalizzi, V., Tanina, A., Grosse, C., Mirgaux, M., Legrand, P., Dias Mirandela, G., Wohlkonig, A., Bifani, P., Wintjens, R.
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Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family.,Megalizzi V, Tanina A, Grosse C, Mirgaux M, Legrand P, Dias Mirandela G, Wohlkonig A, Bifani P, Wintjens R Heliyon. 2024 Nov 16;10(22):e40494. doi: 10.1016/j.heliyon.2024.e40494. , eCollection 2024 Nov 30. PMID:39641026<ref>PMID:39641026</ref>
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Description: Crystal structure of Rv2242 regulator C-terminal fragment (161-414)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Grosse, C]]
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<div class="pdbe-citations 9f80" style="background-color:#fffaf0;"></div>
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[[Category: Legrand, P]]
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== References ==
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[[Category: Wohlkonig, A]]
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<references/>
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[[Category: Tanina, A]]
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__TOC__
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[[Category: Bifani, P]]
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</StructureSection>
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[[Category: Wintjens, R]]
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[[Category: Large Structures]]
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[[Category: Dias Mirandela, G]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Mirgaux, M]]
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[[Category: Bifani P]]
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[[Category: Megalizzi, V]]
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[[Category: Dias Mirandela G]]
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[[Category: Grosse C]]
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[[Category: Legrand P]]
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[[Category: Megalizzi V]]
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[[Category: Mirgaux M]]
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[[Category: Tanina A]]
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[[Category: Wintjens R]]
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[[Category: Wohlkonig A]]

Current revision

Crystal structure of Rv2242 regulator C-terminal fragment (161-414)

PDB ID 9f80

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