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1url

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[[Image:1url.gif|left|200px]]
[[Image:1url.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1url |SIZE=350|CAPTION= <scene name='initialview01'>1url</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1url", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Sia+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HIA:L-HISTIDINE+AMIDE'>HIA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1url| PDB=1url | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1url FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1url OCA], [http://www.ebi.ac.uk/pdbsum/1url PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1url RCSB]</span>
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}}
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'''N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE'''
'''N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE'''
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[[Category: Hilaire, P M.S.]]
[[Category: Hilaire, P M.S.]]
[[Category: Meldal, M.]]
[[Category: Meldal, M.]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: molecular mimicry]]
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[[Category: Molecular mimicry]]
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[[Category: oligosaccharide mimic]]
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[[Category: Oligosaccharide mimic]]
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[[Category: sialoadhesin]]
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[[Category: Sialoadhesin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:35:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:12 2008''
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Revision as of 08:35, 3 May 2008

Image:1url.gif

Template:STRUCTURE 1url

N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE


Overview

Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages. It is a model system for Siglec receptor-mediated cell surface interactions through binding of sialylated glycoconjugates. The N-terminal sialoadhesin domain can mediate sialic acid-binding on its own. The structure of this domain has been determined in complex with a sialic acid-containing heptapeptide, (Ala-Gly-His-Thr(Neu5Ac)-Trp-Gly-His). The affinity of sialoadhesin for this ligand is four times higher than the affinity for the natural linkage 2,3'-sialyllactose. The structure of the glycopeptide complex suggests strategies for ligand optimization and provides possible explanations for the observed differences in specificities among the Siglecs.

About this Structure

1URL is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Complex of sialoadhesin with a glycopeptide ligand., Bukrinsky JT, St Hilaire PM, Meldal M, Crocker PR, Henriksen A, Biochim Biophys Acta. 2004 Nov 1;1702(2):173-9. PMID:15488769 Page seeded by OCA on Sat May 3 11:35:36 2008

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