1urn

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[[Image:1urn.jpg|left|200px]]
[[Image:1urn.jpg|left|200px]]
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{{Structure
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|PDB= 1urn |SIZE=350|CAPTION= <scene name='initialview01'>1urn</scene>, resolution 1.920&Aring;
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The line below this paragraph, containing "STRUCTURE_1urn", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1urn| PDB=1urn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1urn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urn OCA], [http://www.ebi.ac.uk/pdbsum/1urn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1urn RCSB]</span>
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''
'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''
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[[Category: Oubridge, C.]]
[[Category: Oubridge, C.]]
[[Category: Teo, C H.]]
[[Category: Teo, C H.]]
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[[Category: hairpin loop]]
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[[Category: Hairpin loop]]
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[[Category: overhanging base]]
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[[Category: Overhanging base]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: single strand]]
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[[Category: Single strand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:35:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:13 2008''
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Revision as of 08:35, 3 May 2008

Image:1urn.jpg

Template:STRUCTURE 1urn

U1A MUTANT/RNA COMPLEX + GLYCEROL


Overview

The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the surface of the beta-sheet as an open structure, and the AUUGCAC sequence of the loop interacts extensively with the conserved RNP1 and RNP2 motifs and the C-terminal extension of the RNP domain. These interactions include stacking of RNA bases with aromatic side chains of proteins and many direct and water-mediated hydrogen bonds. The structure reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.

About this Structure

1URN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237 Page seeded by OCA on Sat May 3 11:35:44 2008

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