8xtx

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Current revision (09:29, 25 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xtx is ON HOLD until Paper Publication
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==structure of a protein==
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<StructureSection load='8xtx' size='340' side='right'caption='[[8xtx]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xtx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XTX FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xtx OCA], [https://pdbe.org/8xtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xtx RCSB], [https://www.ebi.ac.uk/pdbsum/8xtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xtx ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VACHT_HUMAN VACHT_HUMAN] Presynaptic congenital myasthenic syndromes;Fetal akinesia deformation sequence. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VACHT_HUMAN VACHT_HUMAN] Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (By similarity) (PubMed:20225888, PubMed:8910293). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin.[UniProtKB:O35304][UniProtKB:Q62666]<ref>PMID:20225888</ref> <ref>PMID:25355561</ref> <ref>PMID:8910293</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aequorea victoria]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dong Y]]
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[[Category: Ma Q]]
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[[Category: Meng Y]]
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[[Category: Zhao Y]]

Current revision

structure of a protein

PDB ID 8xtx

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OCA

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