9jka

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Current revision (09:34, 25 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jka is ON HOLD until Paper Publication
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==Human VANGL2 in complex with a PK1 peptide (residues 745-790)==
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<StructureSection load='9jka' size='340' side='right'caption='[[9jka]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jka]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JKA FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jka OCA], [https://pdbe.org/9jka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jka RCSB], [https://www.ebi.ac.uk/pdbsum/9jka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jka ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Isolated anencephaly;Isolated exencephaly. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).[UniProtKB:Q91ZD4]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jian S]]
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[[Category: Song Y]]
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[[Category: Zhang Z]]
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[[Category: Zheng P]]

Current revision

Human VANGL2 in complex with a PK1 peptide (residues 745-790)

PDB ID 9jka

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