1usx

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[[Image:1usx.gif|left|200px]]
[[Image:1usx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1usx |SIZE=350|CAPTION= <scene name='initialview01'>1usx</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1usx", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Dan+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=WIA:METHYL(6S)-1-THIO-L-MANNO-HEXODIALDO-6,2-PYRANOSIDE'>WIA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1usx| PDB=1usx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1usx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usx OCA], [http://www.ebi.ac.uk/pdbsum/1usx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1usx RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE'''
'''CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE'''
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[[Category: Taylor, G.]]
[[Category: Taylor, G.]]
[[Category: Zaitsev, V.]]
[[Category: Zaitsev, V.]]
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[[Category: hemagglutinin]]
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[[Category: Hemagglutinin]]
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[[Category: hemagglutinin-neuraminidase]]
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[[Category: Hemagglutinin-neuraminidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: neuraminidase]]
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[[Category: Neuraminidase]]
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[[Category: sialidase]]
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[[Category: Sialidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:38:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:48 2008''
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Revision as of 08:38, 3 May 2008

Image:1usx.gif

Template:STRUCTURE 1usx

CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE


Overview

Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.

About this Structure

1USX is a Single protein structure of sequence from Newcastle disease virus. Full crystallographic information is available from OCA.

Reference

Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:15016893 Page seeded by OCA on Sat May 3 11:38:36 2008

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OCA

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