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6dvz

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Current revision (09:56, 25 December 2024) (edit) (undo)
 
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<SX load='6dvz' size='340' side='right' viewer='molstar' caption='[[6dvz]], [[Resolution|resolution]] 4.24&Aring;' scene=''>
<SX load='6dvz' size='340' side='right' viewer='molstar' caption='[[6dvz]], [[Resolution|resolution]] 4.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dvz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DVZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DVZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-aminoethyl+diphenylborinate'>FZ4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.24&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-diphenylboranyloxyethanamine'>FZ4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dvz OCA], [http://pdbe.org/6dvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dvz RCSB], [http://www.ebi.ac.uk/pdbsum/6dvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dvz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dvz OCA], [https://pdbe.org/6dvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dvz RCSB], [https://www.ebi.ac.uk/pdbsum/6dvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dvz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
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[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6dvz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6dvz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: McGoldrick, L L]]
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[[Category: McGoldrick LL]]
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[[Category: Singh, A K]]
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[[Category: Singh AK]]
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[[Category: Sobolevsky, A I]]
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[[Category: Sobolevsky AI]]
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[[Category: Calcium channel]]
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[[Category: Membrane protein]]
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[[Category: Trp channel]]
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[[Category: Trpv3]]
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Current revision

Cryo-EM structure of mouse TRPV3-Y564A in complex with 2-Aminoethoxydiphenyl borate (2-APB)

6dvz, resolution 4.24Å

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