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1utr
From Proteopedia
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[[Image:1utr.jpg|left|200px]] | [[Image:1utr.jpg|left|200px]] | ||
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'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)''' | '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)''' | ||
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[[Category: Larsson, C.]] | [[Category: Larsson, C.]] | ||
[[Category: Lund, J.]] | [[Category: Lund, J.]] | ||
| - | [[Category: | + | [[Category: Clara cell phospholipid-binding protein]] |
| - | + | [[Category: Phospholipase a2 inhibitor]] | |
| - | [[Category: | + | [[Category: Progesterone binding]] |
| - | [[Category: | + | [[Category: Uteroglobin]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:40:38 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:40, 3 May 2008
UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Overview
Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
About this Structure
1UTR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672 Page seeded by OCA on Sat May 3 11:40:38 2008
