1utr

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[[Image:1utr.jpg|left|200px]]
[[Image:1utr.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1utr |SIZE=350|CAPTION= <scene name='initialview01'>1utr</scene>
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The line below this paragraph, containing "STRUCTURE_1utr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PCB:4,4&#39;-BIS([H]METHYLSULFONYL)-2,2&#39;,5,5&#39;-TETRACHLOROBIPHENYL'>PCB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1utr| PDB=1utr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1utr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1utr OCA], [http://www.ebi.ac.uk/pdbsum/1utr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1utr RCSB]</span>
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}}
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'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''
'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''
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[[Category: Larsson, C.]]
[[Category: Larsson, C.]]
[[Category: Lund, J.]]
[[Category: Lund, J.]]
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[[Category: clara cell 17 kda protein (cc10)]]
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[[Category: Clara cell phospholipid-binding protein]]
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[[Category: clara cell phospholipid-binding protein]]
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[[Category: Phospholipase a2 inhibitor]]
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[[Category: phospholipase a2 inhibitor]]
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[[Category: Progesterone binding]]
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[[Category: progesterone binding]]
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[[Category: Uteroglobin]]
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[[Category: uteroglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:40:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:08 2008''
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Revision as of 08:40, 3 May 2008

Image:1utr.jpg

Template:STRUCTURE 1utr

UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)


Overview

Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.

About this Structure

1UTR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672 Page seeded by OCA on Sat May 3 11:40:38 2008

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