1uus

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[[Image:1uus.jpg|left|200px]]
[[Image:1uus.jpg|left|200px]]
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{{Structure
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|PDB= 1uus |SIZE=350|CAPTION= <scene name='initialview01'>1uus</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1uus", creates the "Structure Box" on the page.
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|SITE=
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{{STRUCTURE_1uus| PDB=1uus | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uus OCA], [http://www.ebi.ac.uk/pdbsum/1uus PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uus RCSB]</span>
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'''STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM'''
'''STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM'''
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[[Category: Soler-Lopez, M.]]
[[Category: Soler-Lopez, M.]]
[[Category: Williams, J G.]]
[[Category: Williams, J G.]]
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[[Category: dictyostelium]]
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[[Category: Dictyostelium]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: stat]]
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[[Category: Stat]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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[[Category: transducer]]
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[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:35 2008''
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Revision as of 08:43, 3 May 2008

Image:1uus.jpg

Template:STRUCTURE 1uus

STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM


Overview

Dd-STATa is a STAT protein which transcriptionally regulates cellular differentiation in Dictyostelium discoideum, the only non-metazoan known to employ SH2 domain signaling. The 2.7 A crystal structure of a tyrosine phosphorylated Dd-STATa homodimer reveals a four-domain architecture similar to that of mammalian STATs 1 and 3, but with an inverted orientation for the coiled-coil domain. Dimerization is mediated by SH2 domain:phosphopeptide interactions and by a direct interaction between SH2 domains. The unliganded Dd-STATa dimer adopts a fully extended conformation remarkably different from that of the DNA-bound mammalian STATs, implying a large conformational change upon target site recognition. Buried hydrophilic residues predicted to destabilize the coiled-coil domain suggest how hydrophobic residues may become exposed and mediate nuclear export. Functional and evolutionary implications for metazoan STAT proteins are discussed.

About this Structure

1UUS is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structure of an activated Dictyostelium STAT in its DNA-unbound form., Soler-Lopez M, Petosa C, Fukuzawa M, Ravelli R, Williams JG, Muller CW, Mol Cell. 2004 Mar 26;13(6):791-804. PMID:15053873 Page seeded by OCA on Sat May 3 11:43:23 2008

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