8qm7

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Current revision (06:08, 15 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8qm7 is ON HOLD until Paper Publication
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==Potential drug binding sites for translation initiation factor eIF4E==
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<StructureSection load='8qm7' size='340' side='right'caption='[[8qm7]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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Authors: Cleasby, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qm7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QM7 FirstGlance]. <br>
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Description: Potential drug binding sites for translation initiation factor eIF4E
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.191&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=W5K:(2~{R})-2-[(1~{R})-1-[4-(2-fluorophenyl)-2-(2-hydroxyethylamino)phenyl]propoxy]propan-1-ol'>W5K</scene></td></tr>
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[[Category: Cleasby, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qm7 OCA], [https://pdbe.org/8qm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qm7 RCSB], [https://www.ebi.ac.uk/pdbsum/8qm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qm7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cleasby A]]

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Potential drug binding sites for translation initiation factor eIF4E

PDB ID 8qm7

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