8xs7
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with FICZ== | |
| - | + | <StructureSection load='8xs7' size='340' side='right'caption='[[8xs7]], [[Resolution|resolution]] 2.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8xs7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XS7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LWI:5,11-dihydroindolo[3,2-b]carbazole-12-carbaldehyde'>A1LWI</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xs7 OCA], [https://pdbe.org/8xs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xs7 RCSB], [https://www.ebi.ac.uk/pdbsum/8xs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xs7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Diao | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Diao X]] | ||
| + | [[Category: Shang Q]] | ||
| + | [[Category: Wu D]] | ||
Current revision
Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with FICZ
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Categories: Homo sapiens | Large Structures | Sus scrofa | Diao X | Shang Q | Wu D
