8xv3

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Current revision (06:14, 15 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xv3 is ON HOLD until Paper Publication
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==Crystal structure of the catalytic domain of human PDE10A complexed with (2-((4-(5-(2-methylpyridin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)methyl)quinolin-4-yl)(2,6-diazaspiro[3.3]heptan-2-yl)methanone==
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<StructureSection load='8xv3' size='340' side='right'caption='[[8xv3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Zhang, F.C., Huang, Y.Y., Luo, H.B., Guo, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XV3 FirstGlance]. <br>
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Description: Crystal structure of the catalytic domain of human PDE10A complexed with (2-((4-(5-(2-methylpyridin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)methyl)quinolin-4-yl)(2,6-diazaspiro[3.3]heptan-2-yl)methanone
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LWO:2,6-diazaspiro[3.3]heptan-2-yl-[2-[[4-[5-(2-methylpyridin-4-yl)-3-(trifluoromethyl)pyrazol-1-yl]phenoxy]methyl]quinolin-4-yl]methanone'>A1LWO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Luo, H.B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xv3 OCA], [https://pdbe.org/8xv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xv3 RCSB], [https://www.ebi.ac.uk/pdbsum/8xv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xv3 ProSAT]</span></td></tr>
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[[Category: Huang, Y.Y]]
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</table>
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[[Category: Zhang, F.C]]
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== Function ==
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[[Category: Guo, L]]
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Guo L]]
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[[Category: Huang YY]]
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[[Category: Luo HB]]
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[[Category: Zhang FC]]

Current revision

Crystal structure of the catalytic domain of human PDE10A complexed with (2-((4-(5-(2-methylpyridin-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)methyl)quinolin-4-yl)(2,6-diazaspiro[3.3]heptan-2-yl)methanone

PDB ID 8xv3

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