9dwm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==DNA polymerase Beta bound to a nucleosome containing a 1-nt gap at SHL-5.5== | |
| - | + | <StructureSection load='9dwm' size='340' side='right'caption='[[9dwm]], [[Resolution|resolution]] 4.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dwm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DWM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dwm OCA], [https://pdbe.org/9dwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dwm RCSB], [https://www.ebi.ac.uk/pdbsum/9dwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dwm ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Freudenthal BD]] | ||
| + | [[Category: Ryan BJ]] | ||
| + | [[Category: Weaver TM]] | ||
Current revision
DNA polymerase Beta bound to a nucleosome containing a 1-nt gap at SHL-5.5
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