CD69
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3hup' size='350' side='right' caption='Structure of human CD69 | + | <StructureSection load='3hup' size='350' side='right' caption='Structure of human CD69 extracellular domain dimer complex with Cl- (green) and Na+ (purple) ions (PDB entry [[3hup]])' scene='55/552187/Cv/1'> |
| - | '''CD69''' ('''Cluster of Differentiation 69''') is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. <ref>PMID:11101293</ref> <scene name='55/552187/Cv/3'>Na ion coordination site</scene> of CD69 | + | '''CD69''' ('''Cluster of Differentiation 69''') is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. <ref>PMID:11101293</ref> <scene name='55/552187/Cv/3'>Na ion coordination site</scene> of CD69 extracellular domain dimer complex.<ref>PMID:20054122</ref> Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
==3D structures of CD69== | ==3D structures of CD69== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1e87]], [[1e8i]], [[1fm5]], [[3cck]], [[3hup]] – hCD69 | + | [[1e87]], [[1e8i]], [[1fm5]], [[3cck]], [[3hup]] – hCD69 extracellular domain 70-199 – human <br /> |
| + | [[8g94]] – hCD69 + S1PR1 + Gi proteins + ScfV – Cryo EM<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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3D structures of CD69
Updated on 20-January-2025
1e87, 1e8i, 1fm5, 3cck, 3hup – hCD69 extracellular domain 70-199 – human
8g94 – hCD69 + S1PR1 + Gi proteins + ScfV – Cryo EM
References
- ↑ Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. Biochemistry. 2000 Dec 5;39(48):14779-86. PMID:11101293
- ↑ Kolenko P, Skalova T, Vanek O, Stepankova A, Duskova J, Hasek J, Bezouska K, Dohnalek J. The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1258-60. Epub 2009 Nov 27. PMID:20054122 doi:10.1107/S1744309109043152
