1uwp

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[[Image:1uwp.gif|left|200px]]
[[Image:1uwp.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1uwp", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=HC4:4&#39;-HYDROXYCINNAMIC+ACID'>HC4</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1uwp| PDB=1uwp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uwp OCA], [http://www.ebi.ac.uk/pdbsum/1uwp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uwp RCSB]</span>
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'''INITIAL EVENTS IN THE PHOTOCYCLE OF PHOTOACTIVE YELLOW PROTEIN'''
'''INITIAL EVENTS IN THE PHOTOCYCLE OF PHOTOACTIVE YELLOW PROTEIN'''
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[[Category: Kort, R.]]
[[Category: Kort, R.]]
[[Category: Ravelli, R B.G.]]
[[Category: Ravelli, R B.G.]]
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[[Category: domain]]
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[[Category: Domain]]
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[[Category: fold photocycle]]
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[[Category: Fold photocycle]]
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[[Category: gaf]]
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[[Category: Gaf]]
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[[Category: lov]]
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[[Category: Lov]]
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[[Category: pa]]
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[[Category: Pa]]
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[[Category: photoactive]]
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[[Category: Photoactive]]
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[[Category: photoreceptor]]
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[[Category: Photoreceptor]]
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[[Category: signaling protein]]
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[[Category: Signaling protein]]
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[[Category: yellow]]
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[[Category: Yellow]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:47:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:16:20 2008''
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Revision as of 08:47, 3 May 2008

Image:1uwp.gif

Template:STRUCTURE 1uwp

INITIAL EVENTS IN THE PHOTOCYCLE OF PHOTOACTIVE YELLOW PROTEIN


Overview

The light-induced isomerization of a double bond is the key event that allows the conversion of light energy into a structural change in photoactive proteins for many light-mediated biological processes, such as vision, photosynthesis, photomorphogenesis, and photo movement. Cofactors such as retinals, linear tetrapyrroles, and 4-hydroxy-cinnamic acid have been selected by nature that provide the essential double bond to transduce the light signal into a conformational change and eventually, a physiological response. Here we report the first events after light excitation of the latter chromophore, containing a single ethylene double bond, in a low temperature crystallographic study of the photoactive yellow protein. We measured experimental phases to overcome possible model bias, corrected for minimized radiation damage, and measured absorption spectra of crystals to analyze the photoproducts formed. The data show a mechanism for the light activation of photoactive yellow protein, where the energy to drive the remainder of the conformational changes is stored in a slightly strained but fully cis-chromophore configuration. In addition, our data indicate a role for backbone rearrangements during the very early structural events.

About this Structure

1UWP is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

Reference

Initial events in the photocycle of photoactive yellow protein., Kort R, Hellingwerf KJ, Ravelli RB, J Biol Chem. 2004 Jun 18;279(25):26417-24. Epub 2004 Mar 16. PMID:15026418 Page seeded by OCA on Sat May 3 11:47:12 2008

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