8jsr

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Current revision (10:10, 22 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8jsr is ON HOLD until 2026-03-05
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==Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex==
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<StructureSection load='8jsr' size='340' side='right'caption='[[8jsr]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jsr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JSR FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UYI:2-azanyl-~{N}-[(2~{R})-1-[(3~{R})-3-[dimethylamino(methyl)carbamoyl]-3-(phenylmethyl)piperidin-1-yl]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]-2-methyl-propanamide'>UYI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jsr OCA], [https://pdbe.org/8jsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jsr RCSB], [https://www.ebi.ac.uk/pdbsum/8jsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jsr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GHSR_HUMAN GHSR_HUMAN] Short stature due to GHSR deficiency. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GHSR_HUMAN GHSR_HUMAN] Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).<ref>PMID:10604470</ref> <ref>PMID:11322507</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Asada H]]
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[[Category: Im D]]
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[[Category: Iwata S]]
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[[Category: Shimura Y]]

Current revision

Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex

PDB ID 8jsr

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